Aug 14, 2024 · Antibodies are critical reagents used in a variety of assays and protocols in biomedical and clinical research. The ability to detect, quantify, enrich, localize, and/or perturb the function of a target protein – even when present in a complex protein mixture, such as a cell lysate or tissue slice, or even in an intact organism – is key to many biomedical research studies.

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd ...

Aug 6, 2020 · First, we asked if equilibration was demonstrated. By definition, an equilibrium state is invariant with time. So, determining a binding equilibrium constant requires showing that there is no change in the amount of bound complex over time.

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.

Jan 31, 2025 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...

2 Peer review. eLife editors - who are all active researchers - discuss new submissions and decide which will be peer reviewed. The criteria used by the editors are discussed in “How and why eLife selects papers for peer review”.. Each peer reviewer is asked to write a Public Review of the article, and to recommend ways in which the authors could improve it.

Jan 28, 2025 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...

eLife changed its approach to peer review in 2023 to better convey the assessments made by editors and reviewers. Every Reviewed Preprint published in the journal now includes an eLife Assessment written by the editor who oversaw the review process and the peer reviewers.

Oct 7, 2024 · Gene fusions are common mutations that have been linked to several types of cancer, most notably chronic myelogenous leukemia, which is a result of the BCR gene on chromosome 22 fusing with the ABL gene on chromosome 9 (Nowell and Hungerford, 1960).Identifying fusion genes, and investigating the molecular behavior of the chimeric fusion proteins that arise from these mutations, may help with ...

Jul 17, 2024 · Experiments with the Confetti reporter system in mice revealed that hundreds of HSPCs in the embryo contribute to hematopoiesis in adults, and that expansion of these precursors is limited in the fetal liver (Ganuza et al., 2017; Ganuza et al., 2022).However, the previous mathematical model used to quantify the number of precursors was only tested for cell counts between 50 and 2,500 cells ...