Targeted protein degradation (TPD) is transforming drug discovery by leveraging the cell’s natural protein disposal systems ...

GBA1 mutations alone do not explain lysosomal dysfunction in PD. Loss of endosomal recycling proteins cripple this lysosomal enzyme. Without a protein called COMMD3, cells spit out would-be lysosomal ...

Protein degradation of BTK is ideal because it is a known target in the oncology space. Nurix believes that BTK degradation may end up being superior to that of BTK inhibition. While this remains ...

Department of Chemistry, Shanghai Stomatological Hospital, State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, People’s ...

Lysosome impairment contributes to many diseases ... has uncovered the molecular mechanism by which the key autophagy protein ATG-9 promotes the repair of damaged lysosomes by regulating ...

Genes associated with lysosomal dysfunction increase the risk of Parkinson ... The key lies in the Commander complex, involved in the transport of proteins to this organelle. This discovery raises the ...

Instead, it prevents lysosomal trafficking and degradation of the LDL receptor. This could make the drug more effective at freeing up LDL receptors to lower LDL. The randomized, double-blind ...

The researchers saw a similar phenomenon in mouse models for two other LSDs—palmitoyl-protein thioesterase 1 deficiency and lysosomal chloride channel deficiency. These and other LSD mouse ...

Using CRISPR interference to screen the entire genome, scientists identified how Commander proteins impact lysosomal function — a key cellular recycling system tied to Parkinson’s pathology. These ...

comes together to play a previously unrecognized role in delivering specific proteins to the lysosome, a part of the cell that acts like a recycling center, breaking down waste materials, old cell ...

comes together to play a previously unrecognized role in delivering specific proteins to the lysosome, a part of the cell that acts like a recycling center, breaking down waste materials ...

comes together to play a previously unrecognized role in delivering specific proteins to the lysosome, a part of the cell that acts like a recycling center, breaking down waste materials, old cell ...