Current anticancer treatments essentially target the primary tumor cells that proliferate quickly, but do not effectively ...

Targeted protein degradation (TPD) is transforming drug discovery by leveraging the cell’s natural protein disposal systems ...

Current anticancer treatments essentially target the primary tumour cells that proliferate quickly, but do not effectively ...

DHHC5 mediates the palmitoylation of CRYBG1, an actin-binding protein, thereby regulating ... CRYBG1 led to increased ubiquitination and lysosomal degradation of VEGFR2, reducing its localization ...

MPS IIIB is a rare, inherited autosomal recessive disease caused by a deficiency in the activity of NAGLU or an N-acetylglucosaminidase, a lysosomal enzyme required for the degradation of the ...

Department of Chemistry, Shanghai Stomatological Hospital, State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, People’s ...

autophagy induction signaling (A), membrane nucleation/AP formation (B), autophagy adaptor proteins (C) and AL formation/substrate degradation (e.g., lysosomal hydrolases or structural components)(D).

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

GBA1 mutations alone do not explain lysosomal dysfunction in PD. Loss of endosomal recycling proteins cripple this lysosomal enzyme. Without a protein called COMMD3, cells spit out would-be lysosomal ...