Consider cross-hypersensitivity to other aminoglycosides, and the possibility that patients who become sensitized to topical neomycin may also be sensitive to other topical and/or systemic ...

Neomycin is the most commonly used topical antibiotic in the United States and in many European countries (Marks et al., 2002). It is available in both prescription and over-the-counter preparations.

Many vaccines contain trace amounts of neomycin to prevent bacterial contamination during the manufacturing process. As a topical medicament, neomycin elicits a high sensitization rate.