Mitochondrial pathology and some treatments affect the mitochondrial membrane potential. Disrupting the MMP results in more pronounced calcium spikes; chaotic, dysynchronized release; inhibition of ...

Many mitochondrial diseases have been difficult to study and treat due to the inherent challenges in accessing mitochondrial DNA (mtDNA). Now, researchers have optimized mitochondrial-targeted ...

A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent ...

A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent ...

Dysregulation at any level, such as excessive uptake or impaired efflux, leads to mitochondrial Ca 2+ overload, triggering ROS production, mitochondrial membrane potential loss, and permeability ...

Mitochondrial function depends on the intricate shape, membrane ultrastructure, and dynamics of the organelle. Abnormalities in these aspects can lead to organelle dysfunction and ultimately result in ...

Elamipretide, a cell-permeable peptide compound, is designed to improve mitochondrial function by targeting the inner mitochondrial membrane where it binds reversibly to cardiolipin.

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...