Targeted protein degradation (TPD) has emerged as a novel therapeutic modality that harnesses intracellular proteasomal and lysosomal protein-degradation pathways for selective elimination of ...

Targeted protein degradation (TPD) is transforming drug discovery by leveraging the cell’s natural protein disposal systems ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Genes associated with lysosomal dysfunction increase the risk of Parkinson ... The key lies in the Commander complex, involved in the transport of proteins to this organelle. This discovery raises the ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

Protein degradation: is the process by which cells ... the ubiquitin-proteasome system for intracellular proteins and the lysosomal proteolysis pathway, which degrades extracellular proteins ...

We discovered that fibroblasts and cardiac myocytes secrete mitochondria inside extracellular vesicles (EV) when their lysosomal ... lysosomes for degradation or ship everything to the plasma membrane ...

(2) Ubiquitinated outer mitochondrial membrane proteins are extracted ... shaped mitochondrial spheroids and acquire lysosomal contents for possible degradation. (5) Canonical autophagosomes ...

Lysosome impairment contributes to many diseases ... has uncovered the molecular mechanism by which the key autophagy protein ATG-9 promotes the repair of damaged lysosomes by regulating ...