Targeted protein degradation (TPD) has emerged as a novel therapeutic modality that harnesses intracellular proteasomal and lysosomal protein-degradation pathways for selective elimination of ...

The fight against cancer often begins with uncovering hidden players, and this study reveals one such key player: an unexpected class of abbreviated N-glycans. These molecules, upregulated in cancer ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

an important protein for cellular communication and plasticity, pre- and postsynaptically at the NMJ. We hypothesized that the reason for this reduction of EV cargoes in nwk mutants is that cargoes ...

Lysosomes are organelles found within nearly all eukaryotic cells and are responsible for breaking down larger molecules such as proteins, fats and carbs. Lysosomal exocytosis occurs when the ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in ... occurs on endocytic vesicles immediately prior to lysosome fusion and is required for the efficient ...