Southwestern Indiana is an 11-county region of southern Indiana, United States located at the southernmost and westernmost part of the state. As of the 2010 census, the region's combined population is 474,251. Evansville, Indiana's third-largest city, is the primary hub for the region, as well as the primary regional hub for a tri-state area that includes Kent…Southwestern Indiana is an 11-county region of southern Indiana, United States located at the southernmost and westernmost part of the state. As of the 2010 census, the region's combined population is 474,251. Evansville, Indiana's third-largest city, is the primary hub for the region, as well as the primary regional hub for a tri-state area that includes Kentucky and Illinois. Other regional hubs include Jasper, Vincennes, and Washington. Although part of a Midwestern state, certain parts of the region, largely along the Ohio River, may reflect some similarities with the neighboring Upland South, rather than the rest of the Midwest; the area is Midwest with occasional Southern influence, rather than Southern with a Midwest influence.